Diethyl Ether → N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

HRID 4625Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 4625
[CH2:1]([N:3]([CH2:6]C)[CH2:4]C)C.[N:8]1([CH2:14][C:15]2[CH:16]=[C:17]([CH:27]=[CH:28][CH:29]=2)[O:18][CH2:19][CH2:20][CH2:21][NH:22][C:23]([NH:25][NH2:26])=[O:24])[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.CC[O:32]CC>>[CH3:1][N:3]([CH3:6])[C:4]([NH:26][NH:25][C:23]([NH:22][CH2:21][CH2:20][CH2:19][O:18][C:17]1[CH:27]=[CH:28][CH:29]=[C:15]([CH2:14][N:8]2[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]2)[CH:16]=1)=[O:24])=[O:32]

Komponenten

4

Edukt 3

HCID 3283Diethyl EtherHCID 8471TriethylamineHCID 13657330N-(3-{3-[(Piperidin-1-yl)methyl]phenoxy}propyl)hydrazinecarboxamide

Produkt 1

HCID 13657354N,N-Dimethyl-N'-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-1,2-hydrazine dicarboxamide

Versuchsvorschrift

0.6 ml (4 mmol) of triethylamine and 0.4 ml (4 mmol) of N,N-dimethyl-carbamide chloride are added to 1.2 g (4 mmol) of N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]hydrazine carboxamide in 20 ml of ether and the reaction mixture is stirred for 12 hours. Solid triethylammonium chloride is filtered off and the filtrate is concentrated by evaporation under vacuum.

Aufarbeitung

  1. filtrationSolid triethylammonium chloride is filtered off
  2. concentrationthe filtrate is concentrated by evaporation under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d528eaedefc846aebb42fe733e14626e
Quelldatensatz
uspto-grants-1988_02
Patentnummer
US04727081

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