Bromine → 2-Bromo-4-(hydroxymethyl)-2,4-dimethyl-3-pentanone

HRID 462861

Reaktionsgleichung

Reaktionsgleichung von HRID 462861
[OH:1][CH2:2][C:3]([CH3:10])([CH3:9])[C:4](=[O:8])[CH:5]([CH3:7])[CH3:6].[Br:11]Br>C(Cl)(Cl)Cl>[Br:11][C:5]([CH3:7])([CH3:6])[C:4](=[O:8])[C:3]([CH3:10])([CH3:9])[CH2:2][OH:1]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 5191913-Pentanone, 1-hydroxy-2,2,4-trimethyl-

Produkt 1

HCID 137335652-Bromo-4-(hydroxymethyl)-2,4-dimethyl-3-pentanone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel2×

Versuchsvorschrift

To a stirred, refluxing solution of 69 g. (0.48 mole) of 1-hydroxy-2,2,4-trimethylpentan-3-one in 500 ml. of chloroform was added dropwise a solution of 77 g. (0.48 mole) bromine in 100 ml. of chloroform. When the addition was completed the mixture was stirred at reflux for one hour, allowed to cool and stand overnight at room temperature. Evaporation of solvent at reduced pressure afforded 127 g. of product which was used in the next step without purification.

Aufarbeitung

  1. temperatureTo a stirred, refluxing solution of 69 g
  2. additionWhen the addition
  3. temperatureat reflux for one hour
  4. temperatureto cool
  5. customEvaporation of solvent at reduced pressure
  6. customafforded 127 g
  7. customof product which was used in the next step without purification

Quellen und Nachweise

ORD-Eintrag
ord-12ee722b2ee0441ebd8444e27ecaf4a3
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04517379

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