Sodium Hydroxide → 1-(4-Amino-3-benzoylphenyl)ethan-1-one

HRID 463488Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 463488
[NH2:1][C:2]1[CH:15]=[CH:14][C:13]([C:16]2([CH3:21])OCC[O:17]2)=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].Cl(O)(=O)(=O)=O.[OH-].[Na+]>C(O)C>[C:16]([C:13]1[CH:14]=[CH:15][C:2]([NH2:1])=[C:3]([CH:12]=1)[C:4]([C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:5])(=[O:17])[CH3:21]

Komponenten

5

Edukt 3

HCID 14798Sodium HydroxideHCID 24247Perchloric AcidHCID 21828105[2-Amino-5-(2-methyl-1,3-dioxolan-2-yl)phenyl](phenyl)methanone

Produkt 1

HCID 132971931-(4-Amino-3-benzoylphenyl)ethan-1-oneAusbeute 93,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Amino-5-(2-methyl-1,3-dioxolan-2-yl)benzophenone (1.0 g, 3.54 mmol) was dissolved in 30 ml absolute ethanol. To this was added 1M perchloric acid (14 ml). The resulting mixture was stirred at room temperature for 18 hrs. The mixture was made basic with 3N sodium hydroxide solution and then extracted with several portions of methylene chloride. The combined methylene chloride extracts were washed with water, dried with anhydrous sodium sulfate, and evaporated to yield a yellow product (0.79 g) of mp. 158°-161° C. A portion of the product was recrystallized from a mixture of methylene chloride and hexane to yield material of mp. 158°-162° C.

Aufarbeitung

  1. extractionextracted with several portions of methylene chloride
  2. washThe combined methylene chloride extracts were washed with water
  3. dry with materialdried with anhydrous sodium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b35946f6cbbc4a0598018d04b45944b4
Quelldatensatz
uspto-grants-1985_05
Patentnummer
US04519937

Notizen zur Reaktion

Wird geladen…