Sodium Hydroxide → 4-[(Methylsulfonyl)amino]benzoic acid sodium salt

HRID 463672

Reaktionsgleichung

Reaktionsgleichung von HRID 463672
[OH-].[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]>O>[Na+:2].[CH3:3][S:4]([NH:7][C:8]1[CH:16]=[CH:15][C:11]([C:12]([O-:14])=[O:13])=[CH:10][CH:9]=1)(=[O:6])=[O:5]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 2506534-(Methylsulfonamido)benzoic acid

Produkt 1

HCID 236984714-[(Methylsulfonyl)amino]benzoic acid sodium saltAusbeute 97,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

To 500 ml of water is added 63.4 g (1.59 mole) of sodium hydroxide and the mixture is stirred until all the solid has dissolved. To this is slowly added 310 g (1.44 mole) of 4-[(methylsulfonyl)amino]benzoic acid. The reaction is stirred for 15 minutes at ambient temperature after all the solid has dissolved. After removal of the water in vacuo, the residue is triturated with isopropyl alcohol, evaporated, triturated with acetone and concentrated in vacuo. The solid is dried under vacuum for 72 hours to provide 333.7 g of the title compound.

Aufarbeitung

  1. dissolutionhas dissolved
  2. stirringThe reaction is stirred for 15 minutes at ambient temperature after all the solid
  3. dissolutionhas dissolved
  4. customAfter removal of the water in vacuo
  5. customthe residue is triturated with isopropyl alcohol
  6. customevaporated
  7. customtriturated with acetone
  8. concentrationconcentrated in vacuo
  9. customThe solid is dried under vacuum for 72 hours

Quellen und Nachweise

ORD-Eintrag
ord-d3aec6aa7e4f4b75b813675422581f18
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04544654

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