Dibenzylamine → 2-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide

HRID 463719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 463719
Cl[CH2:2][C:3]([NH:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=1[O:12][CH3:13])=[O:4].[CH2:14]([NH:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>C1(C)C=CC=CC=1>[C:15]1([CH2:14][N:21]([CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH2:2][C:3]([NH:5][C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[O:12][CH3:13])=[O:4])[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

Komponenten

4

Edukt 2

HCID 7656DibenzylamineHCID 416472-Chloro-N-(2-methoxyphenyl)acetamide

Produkt 1

HCID 135605532-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamideAusbeute 82,6 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

To a stirred solution of 28.1 g of 2-chloro-N-(2-methoxyphenyl)acetamide (C.A. 50, 8730i) in 200 ml toluene was added 58.3 g of dibenzylamine and refluxed for 48 hours. After separation of dibenzylamine hydrochloride, the solvent was removed from the reaction mixture. Crystallization of the residue from isopropylether gave 41.9 g colorless crystals of 2-[bis(phenylmethyl)amino]-N-(2-methoxyphenyl)acetamide, mp 92°-94°.

Aufarbeitung

  1. temperaturerefluxed for 48 hours
  2. customAfter separation of dibenzylamine hydrochloride
  3. customthe solvent was removed from the reaction mixture
  4. customCrystallization of the residue from isopropylether

Quellen und Nachweise

ORD-Eintrag
ord-c24279feb3d043638f127fce00c6df15
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04544657

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