Diethylamine → N,N-diethyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine

HRID 464288

Reaktionsgleichung

Reaktionsgleichung von HRID 464288
Cl[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2.Cl[C:17]1[C:18]2[N:19](C=NN=2)[C:20]2C(N=1)=CC=C[CH:21]=2.C(NCC)C.C(NCCC)CC>>[CH2:18]([N:19]([CH2:20][CH3:21])[C:2]1[C:3]2[N:4]([C:12]([CH3:15])=[N:13][N:14]=2)[C:5]2[C:10]([N:11]=1)=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH3:17]

Komponenten

5

Edukt 4

HCID 8021DiethylamineHCID 8902DipropylamineHCID 11261184-Chloro[1,2,4]triazolo[4,3-a]quinoxalineHCID 27686434-Chloro-1-methyl[1,2,4]triazolo[4,3-a]quinoxaline

Produkt 1

HCID 899504N,N-diethyl-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amineAusbeute 54 %

Versuchsvorschrift

This compound was prepared by the method of Example 11, utilizing 4-chloro-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 3) as starting material in place of 4-chloro-[1,2,4]triazolo[4,3-a]quinoxaline (the product of Example 2) and diethylamine as reagent in place of di-n-propylamine. The crude product obtained was recrystallized from chloroform and then from cyclohexane to afford 7.2 g. (54% yield) of pure 4-diethylamino-1-methyl-[1,2,4]triazolo[4,3-a]quinoxaline, m.p. 123°-125° C.

Aufarbeitung

  1. customThe crude product obtained
  2. customwas recrystallized from chloroform
  3. customfrom cyclohexane to afford 7.2 g

Quellen und Nachweise

ORD-Eintrag
ord-60902d7a6a584149b5bad04a7a52c7f5
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04547501

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