Hydrochloric Acid → 3-Chloro-5-nitro-2(1H)-pyridinone

HRID 464624

Reaktionsgleichung

Reaktionsgleichung von HRID 464624
[N+:1]([C:4]1[CH:5]=[CH:6][C:7](=[O:10])[NH:8][CH:9]=1)([O-:3])=[O:2].Cl.[Cl:12]([O-])(=O)=O.[K+]>O>[Cl:12][C:6]1[C:7](=[O:10])[NH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 794535-Nitropyridin-2-olHCID 6426889Potassium Chlorate

Produkt 1

HCID 3362893-Chloro-5-nitro-2(1H)-pyridinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

5-Nitro-2-pyridone (Aldrich Chemical Company) (100 g, 0.71 mol) was added to 1 liter conc. HCl at room temperature, followed by the dropwise addition of a solution of potassium chlorate (87.5 g, 0.71 mol) in 1.2 liter water. A solid material formed during the addition. The mixture was stirred overnight, filtered, and the collected material recrystallized from 50 percent aqueous ethanol. The yield was 77.2 g, 62 percent, m.p. 196°-198° C.

Aufarbeitung

  1. customA solid material formed during the addition
  2. filtrationfiltered
  3. customthe collected material recrystallized from 50 percent aqueous ethanol

Quellen und Nachweise

ORD-Eintrag
ord-14f5395969a04bf0b5ae561b9969b5b2
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04548888

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