Guanidine Hydrochloride → HCID 178512622, Verbindung

HRID 464699Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 464699
Cl.[NH2:2][C:3]([NH2:5])=[NH:4].[Na].[N+:7]([C:10]1[CH:11]=[C:12]([C:16]2[N:20]=[C:19](C(Cl)(Cl)Cl)[O:18][N:17]=2)[CH:13]=[CH:14][CH:15]=1)([O-:9])=[O:8]>C(O)C>[NH:4]([C:19]1[O:18][N:17]=[C:16]([C:12]2[CH:13]=[CH:14][CH:15]=[C:10]([N+:7]([O-:9])=[O:8])[CH:11]=2)[N:20]=1)[C:3]([NH2:5])=[NH:2]

Komponenten

5

Edukt 3

HCID 5742Guanidine HydrochlorideHCID 5360545SodiumHCID 202163883-(3-Nitrophenyl)-5-(trichloromethyl)-1,2,4-oxadiazole

Produkt 1

HCID 178512622HCID 178512622, VerbindungAusbeute 84 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

7.3 gm of guanidine hydrochloride were added in portions to a solution of 1.8 gm of sodium in 100 ml of ethanol. After 30 minutes of stirring, 22.5 gm of 3-(3-nitro-phenyl)-5-trichloromethyl-1,2,4-oxadiazole were added. The solid which separated out overnight was filtered off and dried, yielding 15.2 gm of the title compound, m.p. 290°-291° C.

Aufarbeitung

  1. customThe solid which separated out overnight
  2. filtrationwas filtered off
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-13f58b3c96d84e3f98d75fa7b3b957e8
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04548944

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