Nitromethane → Methyl 3-(4-chlorophenyl)-4-nitrobutanoate

HRID 464723

Reaktionsgleichung

Reaktionsgleichung von HRID 464723
[Cl:1][C:2]1[CH:13]=[CH:12][C:5]([CH:6]=[CH:7][C:8]([O:10][CH3:11])=[O:9])=[CH:4][CH:3]=1.[N+:14]([CH3:17])([O-:16])=[O:15].CN(C)C(=N)N(C)C>C(OCC)C.Cl>[CH3:11][O:10][C:8](=[O:9])[CH2:7][CH:6]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:13][CH:12]=1)[CH2:17][N+:14]([O-:16])=[O:15]

Komponenten

6

Edukt 3

HCID 6375NitromethaneHCID 664601,1,3,3-TetramethylguanidineHCID 98955Methyl 3-(4-chlorophenyl)-2-propenoate

Produkt 1

HCID 14931333Methyl 3-(4-chlorophenyl)-4-nitrobutanoate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 313Hydrochloric AcidLösungsmittelHCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A mixture of 290 g of p-chlorocinnamic acid, methyl ester, 500 g of nitromethane and 39 g of tetramethylguanidine is allowed to stir for 72 hours. The solution is diluted with ethyl ether and aqueous hydrochloric acid solution (1 N, 1 liter) is added. The organic layer is separated, dried over anhydrous magnesium sulfate, and evaporated to give 4-nitro-3-(4-chlorophenyl)butanoic acid methyl ester.

Aufarbeitung

  1. additionis added
  2. customThe organic layer is separated
  3. dry with materialdried over anhydrous magnesium sulfate
  4. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-e8769266aa604824bfe4c0763b4a3ee2
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04548947

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