2-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanol → 2-[(3-Pyrrolidinylmethyl)amino]ethanol

HRID 464972

Reaktionsgleichung

Reaktionsgleichung von HRID 464972
C1(C[N:8]2[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]2)C=CC=CC=1.[H][H]>[Pd].CO>[NH:8]1[CH2:12][CH2:11][CH:10]([CH2:13][NH:14][CH2:15][CH2:16][OH:17])[CH2:9]1

Komponenten

5

Edukt 2

HCID 142808882-(((1-Benzylpyrrolidin-3-yl)methyl)amino)ethanolHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 134918032-[(3-Pyrrolidinylmethyl)amino]ethanolAusbeute 57,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A mixture of 32.32 g of 2-[[[1-(phenylmethyl)-3-pyrrolidinyl]methyl]amino]ethanol, 330 ml of methanol and 3 g of 20% palladium on charcoal was shaken in an atmosphere of hydrogen at about 50 psi and at room temperature for 18 hours. The solvents were then removed at reduced pressure. The residue was distilled under vacuum, bp 129°-131° C. (1.5 mm) to give 11.43 g of 2-[(3-pyrrolidinylmethyl)amino]ethanol.

Aufarbeitung

  1. customThe solvents were then removed at reduced pressure
  2. distillationThe residue was distilled under vacuum, bp 129°-131° C. (1.5 mm)

Quellen und Nachweise

ORD-Eintrag
ord-1711341919a14cd7ace42d59171115b4
Quelldatensatz
uspto-grants-1985_10
Patentnummer
US04550103

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