Piperidine → O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

HRID 465298Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 465298
[P:1](=[O:9])([N:6]=[C:7]=[O:8])([S:4][CH3:5])[O:2][CH3:3].[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>CCOCC>[N:10]1([C:7]([NH:6][P:1](=[O:9])([S:4][CH3:5])[O:2][CH3:3])=[O:8])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Komponenten

4

Edukt 2

HCID 8082PiperidineHCID 14879948O,S-dimethyl phosphoroisocyanatidothioate

Produkt 1

HCID 19873990O,S-Dimethyl 1-Piperidinylcarbonylphosphoramidothioate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3283Diethyl EtherLösungsmittel

Versuchsvorschrift

A solution of 6.0 grams (g) of O,S-dimethyl phosphoroisocyanatidothioate in 100 milliliters (ml) of ether was cooled to 0° C. and to this was added dropwise with stirring 3.1 g of piperidine. A precipitate began to form almost immediately and after one hour this precipitate was collected by filtration and extracted with ether. It was then recrystallized from toluene-hexane to obtain the title compound as white crystals melting at 96° C.

Aufarbeitung

  1. additionto this was added dropwise
  2. customto form almost immediately and after one hour this precipitate
  3. filtrationwas collected by filtration
  4. extractionextracted with ether
  5. customIt was then recrystallized from toluene-hexane

Quellen und Nachweise

ORD-Eintrag
ord-452fd9f5f47346f1936dbfed9e5ca2b3
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05153184

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