Water → 1-(2-Sulfanylethyl)pyrrolidine-2,5-dione

HRID 465896

Reaktionsgleichung

Reaktionsgleichung von HRID 465896
O.[SH:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[CH2:7][CH2:8][C:9]([OH:11])=O>C1(C)C(C)=CC=CC=1>[SH:2][CH2:3][CH2:4][N:5]1[C:6](=[O:12])[CH2:7][CH2:8][C:9]1=[O:11]

Komponenten

4

Edukt 2

HCID 962WaterHCID 224508284-Oxo-4-[(2-sulfanylethyl)amino]butanoic acid

Produkt 1

HCID 220163571-(2-Sulfanylethyl)pyrrolidine-2,5-dioneAusbeute 100,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 7237O-XyleneLösungsmittel

Reaktionsbedingungen

Temperatur
140 °C

Versuchsvorschrift

In a 100 cm3 reactor fitted with a water separator (Dean Stark) there is heated to a temperature of 140° C. a mixture, stirred under an inert atmosphere, of 20 g of N-(2-mercapto ethyl) succinamic acid in 50 cm3 of xylene. After about 5 hours of reaction, the theoretical amount of water (2 cm3) is removed. The xylene is then distilled under reduced pressure. The crude product is dried and 18 g of a pasty product are obtained which slowly crystallizes at ambient temperature, its characteristics being the same as those of the product prepared following the procedures in section (a) immediately above.

Aufarbeitung

  1. customAfter about 5 hours of reaction
  2. customthe theoretical amount of water (2 cm3) is removed
  3. distillationThe xylene is then distilled under reduced pressure
  4. dry with materialThe crude product is dried

Quellen und Nachweise

ORD-Eintrag
ord-8cd426b10d72487bb13780b129cd085d
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05154918

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