Reaktionsgleichung
O.O.O.O.O.O.O.O.O.[S-2:10].[Na+].[Na+].Cl[C:14]1[CH:19]=[N:18][CH:17]=[CH:16][N:15]=1.Br[C:21]1[S:22][C:23]([N+:26]([O-:28])=[O:27])=[CH:24][N:25]=1.O>CN(C)C=O>[N+:26]([C:23]1[S:22][C:21]([S:10][C:14]2[CH:19]=[N:18][CH:17]=[CH:16][N:15]=2)=[N:25][CH:24]=1)([O-:28])=[O:27]Komponenten
6
Edukt 4
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 40 °C
Versuchsvorschrift
To a solution of 60.0 g (0.25 mol) of sodium sulfide nonahydrate in 500 ml of dimethyl formamide was gradually added 29 g (0.25 mol) of chloropyrazine in 100 ml of dimethyl formamide. The solution was stirred overnight at approximately 40° C. following which 52.5 g (0.25 mol) of 2-bromo-5-nitrothiazole was added as a solid. This reaction mixture was stirred at room temperature for 4 hours. After this period it was poured into water. The resulting precipitate was collected by suction filtration, washed with water and dried. The crude product was crystallized from methanol to yield 38 g (72% yield) of yellowish-gold crystals, m.p. 129°-130° C. A sample was subjected to elemental analysis. The results obtained were as follows:
Aufarbeitung
- additionwas added as a solid
- stirringThis reaction mixture was stirred at room temperature for 4 hours
- filtrationThe resulting precipitate was collected by suction filtration
- washwashed with water
- customdried
- customThe crude product was crystallized from methanol
- customto yield 38 g (72% yield) of yellowish-gold crystals, m.p. 129°-130° C
- customThe results obtained
Quellen und Nachweise
- ORD-Eintrag
- ord-d6a3df8b95524e459345095859e7e471
- Quelldatensatz
- uspto-grants-1979_11
- Patentnummer
- US04174394
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