Hydroxyamine hydrochloride → 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

HRID 466191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466191
[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=O)=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Cl.[NH2:21][OH:22]>N1C=CC=CC=1.C(O)C>[O:1]([C:8]1[CH:9]=[CH:10][C:11]2[O:16][CH2:15][C:14]([CH:17]=[N:21][OH:22])=[CH:13][C:12]=2[CH:19]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 443297Hydroxyamine hydrochlorideHCID 149712656-phenoxy-2H-1-benzopyran-3-carboxaldehyde

Produkt 1

HCID 856778336-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 21975839Pyridine ethanolLösungsmittel

Versuchsvorschrift

6-Phenoxy-2H-1-benzopyran-3-carboxaldehyde (5.00 g, 19.9 mmol) is dissolved in 175 ml of pyridine/ethanol (1:1) and treated with hydroxylamine hydrochloride (2.07 g, 29.7 mmol). The mixture is stirred for 1 hour and partitioned between ether and water. The aqueous layer is extracted with ether, and the ether layer is washed with 2N HCl, dried (MgSO4) and evaporated to give 6-phenoxy-2H-1-benzopyran-3-carboxaldehyde oxime as a pale yellow solid.

Aufarbeitung

  1. custompartitioned between ether and water
  2. extractionThe aqueous layer is extracted with ether
  3. washthe ether layer is washed with 2N HCl
  4. dry with materialdried (MgSO4)
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8e53bd09a0ed4cb3af88766be1a44130
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05155130

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