2-Chloro-1,4-naphthoquinone → 2-Methoxy-1,4-Naphthoquinone

HRID 466208

Reaktionsgleichung

Reaktionsgleichung von HRID 466208
Cl[C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH3:14][O-:15].[Na+]>O1CCCC1>[CH3:14][O:15][C:2]1[C:3](=[O:13])[C:4]2[C:9]([C:10](=[O:12])[CH:11]=1)=[CH:8][CH:7]=[CH:6][CH:5]=2

Komponenten

4

Edukt 2

HCID 138912-Chloro-1,4-naphthoquinoneHCID 10942334Sodium Methoxide

Produkt 1

HCID 168712-Methoxy-1,4-Naphthoquinone

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

A solution of 2-chloro-1,4-naphthoquinone (10.3 g) in tetrahydrofuran (100 mL) was treated with a suspension of sodium methoxide (3.20 g) in tetrahydrofuran (25 mL) at room temperature. After stirring overnight, the mixture was evaporated, and the residue was taken up in ether. The organic layer was washed with brine, dried, filtered and evaporated. Chromatography over silica gel gave 2-methoxy-1,4-naphthoquinone, m.p. 182°-183° C.

Aufarbeitung

  1. customthe mixture was evaporated
  2. washThe organic layer was washed with brine
  3. customdried
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-8900b8b807eb4e4d8e1c978df9624256
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05155132

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