Oxalyl chloride → 2,6-Difluoro-4-methoxybenzoyl chloride

HRID 466489Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466489
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])C=1C(O)=O>C1C=CC=CC=1.CN(C=O)C>[F:7][C:8]1[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[C:13]([F:19])[C:1]=1[C:2]([Cl:4])=[O:3]

Komponenten

5

Edukt 2

HCID 65578Oxalyl chlorideHCID 27782282,6-Difluoro-4-methoxybenzoic acid

Produkt 1

HCID 27787682,6-Difluoro-4-methoxybenzoyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

A solution of oxalyl chloride (36.5 g, 0.29 mol) in dry benzene (50 ml) was added dropwise to a stirred solution of compound 24 (25.5 g, 0.14 mol) and dry DMF (40 drops) in dry benzene (500 ml) at room temperature. The mixture was stirred at room temperature overnight and the excess of oxalyl chloride and benzene were removed in vacuo.

Aufarbeitung

  1. customthe excess of oxalyl chloride and benzene were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-4accdac8a97c4df19fd1dc2bd631cea3
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05156763

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