Hexanoic Acid → 7-Methyl-2-pentyl-3H-imidazo[4,5-b]pyridine

HRID 466694

Reaktionsgleichung

Reaktionsgleichung von HRID 466694
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:9])[CH:5]=[CH:4][N:3]=1.[C:10](O)(=O)[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>>[CH3:9][C:6]1[CH:5]=[CH:4][N:3]=[C:2]2[N:1]=[C:10]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[NH:8][C:7]=12

Komponenten

3

Edukt 2

HCID 8892Hexanoic AcidHCID 3174954-Methylpyridine-2,3-diamine

Produkt 1

HCID 198141217-Methyl-2-pentyl-3H-imidazo[4,5-b]pyridine

Versuchsvorschrift

The title compound was prepared from 2,3-diamino-4-picoline (0.246 g, 2 mmol) and hexanoic acid (0.25 ml, 2 mmols) according to the procedure described in Step 1 of Example 9. The crude product was purified by flash chromatography on silica-gel using EtOAc-MeOH (9:1) to give the pure product (0.28 g, 69%) as a tan colored solid.

Aufarbeitung

  1. customThe crude product was purified by flash chromatography on silica-gel

Quellen und Nachweise

ORD-Eintrag
ord-841ec3cba52e428982d1c07469bac46d
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157026

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