Tetrabutylammonium Fluoride → 1-Decyn-3-ol

HRID 466804Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 466804
C[Si](C)(C)[C:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

Komponenten

4

Edukt 2

HCID 2724141Tetrabutylammonium FluorideHCID 109552841-Decyn-3-ol, 1-(trimethylsilyl)-

Produkt 1

HCID 109207291-Decyn-3-ol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Dissolve 1-trimethylsilyl-1-decyn-3-ol (2.07 g, 9.13 mmol) in tetrahydrofuran (11 mL) and place under an argon atmosphere. Add, by dropwise addition, tetra-n-butylammonium fluoride (11 mL of a 1M solution in tetrahydrofuran, 11 mmol). Stir for 1 hour at room temperature and partition between methylene chloride and water. Separate the organic phase, wash with saturated aqueous sodium chloride, dry (MgSO4), filter and evaporate the solvent in vacuo to give the title compound.

Aufarbeitung

  1. custompartition between methylene chloride and water
  2. customSeparate the organic phase
  3. washwash with saturated aqueous sodium chloride
  4. dry with materialdry (MgSO4)
  5. filtrationfilter
  6. customevaporate the solvent in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-d93a649a9ef541aab87e984dfaebfa16
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05157167

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