Acetyl chloride → Acetamide, N-(2,6-dichlorophenyl)-

HRID 467286Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467286
[Cl:1][C:2]1[CH:8]=[CH:7][CH:6]=[C:5]([Cl:9])[C:3]=1[NH2:4].[C:10](Cl)(=[O:12])[CH3:11]>C(O)(=O)C>[CH3:11][C:10]([NH:4][C:3]1[C:2]([Cl:1])=[CH:8][CH:7]=[CH:6][C:5]=1[Cl:9])=[O:12]

Komponenten

4

Edukt 2

HCID 6367Acetyl chlorideHCID 118462,6-Dichloroaniline

Produkt 1

HCID 28698Acetamide, N-(2,6-dichlorophenyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a mechanically stirred solution of 2,6-dichloroaniline (76 g, 0.047 mol) in 60 mL of glacial acetic acid is added dropwise acetyl chloride (36 mL, 0.5 mol). After the addition is complete, the reaction mixture is heated at 90° C. for 20 minutes. The solution is poured into ice water (500 mL), forming a white precipitate. The solids are filtered, washed with water and dried to give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. form glacial acetic acid).

Aufarbeitung

  1. additionAfter the addition
  2. customforming a white precipitate
  3. filtrationThe solids are filtered
  4. washwashed with water
  5. customdried
  6. customto give the product (91.8 g, 96%, white solid, m.p. 179°-180° C., lit. m.p. 180°-181° C. form glacial acetic acid)

Quellen und Nachweise

ORD-Eintrag
ord-02643af1442b422c9c9cee17f802fdcf
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05159085

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