3-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester → Boc-Phe-betaAla-OH

HRID 467355Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467355
[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]CC1C=CC=CC=1)=[O:16])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO.[Pd]>[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

Komponenten

4

Edukt 1

HCID 136862023-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester

Produkt 1

HCID 14330680Boc-Phe-betaAla-OH

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

3.0 g Boc-Phe-βAla-OBzl was reduced in 50 ml MeOH in the presence of Pd-black as a catalyst, and this was followed by concentration; the resulting residue was dissolved in 30 ml AcOEt, after which it was crystallized with 0.80 ml CHA and collected by filtration.

Aufarbeitung

  1. concentrationthis was followed by concentration
  2. dissolutionthe resulting residue was dissolved in 30 ml AcOEt
  3. customafter which it was crystallized with 0.80 ml CHA
  4. filtrationcollected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-d9e70b58f34e47899769f70bb4eb5d14
Quelldatensatz
uspto-grants-1992_10
Patentnummer
US05159061

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