1,2-Diaminocyclohexane → trans-Bis(methylammine)dichloroplatinum(II)

HRID 46754

Reaktionsgleichung

Reaktionsgleichung von HRID 46754
[Cl:1][Pt-2:2](Cl)(Cl)Cl.[K+].[K+].[NH2:8][CH:9]1[CH2:14][CH2:13][CH2:12][CH2:11][CH:10]1[NH2:15]>O>[CH2:13]1[CH2:14][CH:9]([NH2:8])[CH:10]([NH2:15])[CH2:11][CH2:12]1.[Cl-:1].[Cl-:1].[Pt+2:2]

Komponenten

4

Edukt 2

HCID 46101,2-DiaminocyclohexaneHCID 61440Dipotassium tetrachloroplatinate

Produkt 1

HCID 151742trans-Bis(methylammine)dichloroplatinum(II)Ausbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Versuchsvorschrift

Dichloro (1,2-diaminocyclohexane)platinum (II) was synthesized as described by Gale et al, Research Communications in Chemical Pathology and Pharmacology, Volume 7, No. 3, Pages 529-538, March 1974. Thus, Potassium tetrachloroplatinite, K2Pt Cl4 (20 mM) in 75 ml water was mixed with 1,2-diaminocyclohexane (20 mM) for three hours at room temperature. The insoluble product was removed by filtration, washed with water and then with methanol, and oven-dried. The yield was approximately 90% of theory. The product was then purified by dissolution in dimethylformamide, filtration, and addition of three volumes of methanol or 0.1 N HCl. This product was filtered, washed, and dried as above. The yield in purification was 47%.

Aufarbeitung

  1. customThe insoluble product was removed by filtration
  2. washwashed with water
  3. dry with materialwith methanol, and oven-dried
  4. customThe product was then purified by dissolution in dimethylformamide
  5. filtrationfiltration, and addition of three volumes of methanol or 0.1 N HCl
  6. filtrationThis product was filtered
  7. washwashed
  8. customdried as above
  9. customThe yield in purification

Quellen und Nachweise

ORD-Eintrag
ord-400a75256f4b4d7aad897f30db936aee
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04175133

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