Formaldehyde → 1-Methylpiperidine-2-carboxylic acid

HRID 467553

Reaktionsgleichung

Reaktionsgleichung von HRID 467553
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:7]([OH:9])=[O:8].[CH2:10]=O>C(O)=O>[CH3:10][N:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH:2]1[C:7]([OH:9])=[O:8]

Komponenten

4

Edukt 2

HCID 712FormaldehydeHCID 849Pipecolic Acid

Produkt 1

HCID 4159391-Methylpiperidine-2-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 284Formic AcidLösungsmittel

Versuchsvorschrift

Into a 25 ml 3-necked round bottom flask, was placed piperidine-2-carboxylic acid (975 mg, 7.56 mmol), HCHO (2.0 ml) and HCOOH (2.6 ml). The resulting solution was allowed to react, with stirring, for 5 hours while the temperature was maintained at reflux. The reaction progress was monitored by LCMS. The mixture was then concentrated by evaporation under vacuum using a rotary evaporator. The residue was triturated with 30 ml of Et2O to provide 1-methylpiperidine-2-carboxylic acid of as a white solid (0.5 g, 41%).

Aufarbeitung

  1. customInto a 25 ml 3-necked round bottom flask, was placed
  2. customto react
  3. temperaturewas maintained
  4. temperatureat reflux
  5. concentrationThe mixture was then concentrated by evaporation under vacuum
  6. customa rotary evaporator
  7. customThe residue was triturated with 30 ml of Et2O

Quellen und Nachweise

ORD-Eintrag
ord-9fe4d9224b454ca3abf2f191ce757a97
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623871B2

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