Hydrochloric Acid → HCID 72280550, Verbindung

HRID 467605Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467605
Cl.[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([OH:13])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C)C=O>[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([Cl:17])=[O:13])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 541093814-(1-Piperidinyl)-2-butenoic acid

Produkt 1

HCID 72280550HCID 72280550, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6228DimethylformamideKatalysatorHCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

The HCl salt of 4-Piperidin-1-yl-but-2-enoic acid (250 mg, 1.48 mmol) was dissolved in dichloromethane (15 mL). Dimethylformamide (3 drops) was added. Oxalyl chloride (155 μL, 1.77 mmol) was added slowly and the reaction was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was used as is.

Aufarbeitung

  1. concentrationThe mixture was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-e246df21010a418db268d45e7238ec4b
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623883B2

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