N,1-dimethyl-4-nitropyrazole-3-carboxamide → 4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide

HRID 467636Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 467636
[CH3:1][NH:2][C:3]([C:5]1[C:9]([N+:10]([O-])=O)=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]>C(O)C.[Pd]>[CH3:1][NH:2][C:3]([C:5]1[C:9]([NH2:10])=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]

Komponenten

4

Edukt 1

HCID 1256475N,1-dimethyl-4-nitropyrazole-3-carboxamide

Produkt 1

HCID 70175484-amino-N,1-dimethyl-1H-pyrazole-3-carboxamideAusbeute 98,6 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methylamide (100 mg, 0.5 mmol) in ethanol (4 ml) was flushed with argon and treated with Pd/C 10% (40 mg, 0.04 mmol). The reaction vessel was evacuated and flushed with hydrogen three times and the reaction was stirred at ambient temperature overnight. The reaction mixture was filtrated and the solvent was evaporated to yield a brown viscous oil (76 mg, 91%) which was used without further purification.

Aufarbeitung

  1. customThe reaction vessel was evacuated
  2. customflushed with hydrogen three times
  3. filtrationThe reaction mixture was filtrated
  4. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-c17cc36d9b1b46f3930bbbec2e24b147
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623866B2

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