Bromine → Ethyl 3-bromo-2-oxobutanoate

HRID 467826

Reaktionsgleichung

Reaktionsgleichung von HRID 467826
[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH2:6][CH3:7])[CH3:2].[Br:10]Br>C(Cl)(Cl)Cl>[CH2:1]([O:3][C:4](=[O:9])[C:5](=[O:8])[CH:6]([Br:10])[CH3:7])[CH3:2]

Komponenten

4

Edukt 2

HCID 24408BromineHCID 85195ethyl acetoacetate, sodium salt

Produkt 1

HCID 11117285Ethyl 3-bromo-2-oxobutanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

The 2-oxo-butyric acid ethyl ester prepared above was dissolved in chloroform (100 mL) and bromine (20.964 g, 131.19 mmol) was added dropwise at room temperature. The reaction mixture was allowed to stir for 18 h. Concentration of the reaction mixture under reduced pressure provided 12.0 g of the title compound as an orange oil. 1H NMR (CDCl3) δ 4.39 (q, 2H), 4.32 (q, 1H), 1.88 (d, 3H), 1.39 (t, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-51550b5f38fd48ef9682d22e4781c513
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623890B2

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