Diallyl Disulfide → Allicin

HRID 468086

Reaktionsgleichung

Reaktionsgleichung von HRID 468086
[CH2:1]([S:4][S:5][CH2:6][CH:7]=[CH2:8])[CH:2]=[CH2:3].S([O-])(O[O-])(=O)=[O:10].[K+].[K+]>C(O)C.O>[CH2:3]=[CH:2][CH2:1][S:4](=[O:10])[S:5][CH2:6][CH:7]=[CH2:8]

Komponenten

4

Edukt 2

HCID 16590Diallyl DisulfideHCID 10313463Potassium peroxymonosulphate

Produkt 1

HCID 65036Allicin

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

10 ml of diallyl disulphide (DADS) were stirred into 100 ml ethanol/water (1:1). 20 grams of potassium peroxymonosulfate (Oxone®) was added slowly over 2 hours, and stirred at below 10° C. until no further reaction was observed. The resultant solution was then filtered, and then extracted with diethyl ether (2×50 ml). The diethyl ether layers were combined and washed with 10% brine solution 2×50 ml. The ether layer was dried with magnesium sulfate then reduced to under vacuum. Removal of the solvent produced a yellow oil of pure allicin better than 90% (expressed as a % of pure material). The pure allicin may then be treated as per Example 1 for conversion to ajoene.

Aufarbeitung

  1. filtrationThe resultant solution was then filtered
  2. extractionextracted with diethyl ether (2×50 ml)
  3. washwashed with 10% brine solution 2×50 ml
  4. dry with materialThe ether layer was dried with magnesium sulfate
  5. customRemoval of the solvent

Quellen und Nachweise

ORD-Eintrag
ord-f08523db7f32422489394b230990a836
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08623923B2

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