Potassium Carbonate → Piperazin-1-yl(thiazol-2-yl)methanone
Reaktionsgleichung
FC(F)(F)C([N:5]1[CH2:10][CH2:9][N:8]([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6]1)=O.C([O-])([O-])=O.[K+].[K+]>CO.O>[N:8]1([C:11]([C:13]2[S:14][CH:15]=[CH:16][N:17]=2)=[O:12])[CH2:7][CH2:6][NH:5][CH2:10][CH2:9]1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
A solution of compound 7a (3.8 g, 0.013 mol) and K2CO3 (3.5 g, 0.026 mol) in MeOH (40 mL) and water (10 mL), was stirred for 4 h. The solid was collected by filtration and the solvent evaporated in vacuo to give compound 7b (6.12 g). MS m/z (M+H+) 198.1.
Aufarbeitung
- filtrationThe solid was collected by filtration
- customthe solvent evaporated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-43bff7f50ea547c0b61bdc9a7f055386
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08623858B2
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