Ammonium Chloride → (7-Chloro-1,3-dioxaindan-5-yl)methanol

To a solution of 7-chlorobenzo[d][1,3]dioxole-5-carbaldehyde (6.0 g, 33 mmol) in THF (50 mL) was added NaBH4 (2.5 g, 64 mmol)) in portions at 0° C., The mixture was stirred at this temperature for 30 mm and then poured into aqueous NH4Cl solution. The organic layer was separated, and the aqueous phase was extracted with EtOAc (50 mL×3). The combined extracts were dried over Na2SO4 and evaporated under reduced pressure to afford (7-chlorobenzo[d][1,3]dioxol-5-yl)methanol, which was directly used in the next step.

1. customThe organic layer was separated
2. extractionthe aqueous phase was extracted with EtOAc (50 mL×3)
3. dry with materialThe combined extracts were dried over Na2SO4
4. customevaporated under reduced pressure

ORD-Eintrag

ord-721d231310dc4dd9a0ca9c705dbd586e

Quelldatensatz

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08623905B2