3-Amino-1-propanol → 3-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

HRID 46853

Reaktionsgleichung

Reaktionsgleichung von HRID 46853
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1Cl.[NH2:12][CH2:13][CH2:14][CH2:15][OH:16]>C(O)CCC>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-:10])=[O:9])[C:3]=1[NH:12][CH2:13][CH2:14][CH2:15][OH:16]

Komponenten

4

Edukt 2

HCID 90863-Amino-1-propanolHCID 185552,3-Dichloronitrobenzene

Produkt 1

HCID 203855663-[(2-Chloro-6-nitrophenyl)amino]-1-propanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 2631-ButanolLösungsmittel

Versuchsvorschrift

A mixture of 100 parts of 1,2-dichloro-3-nitrobenzene, 95 parts of 3-amino-1-propanol and 200 parts of butanol is stirred and refluxed overnight. The reaction mixture is cooled and evaporated. The residue is taken up in water and the product is extracted with methylbenzene. The extract is washed with water, dried, filtered and evaporated, yielding 115 parts of 3-[(2-chloro-6-nitrophenyl)amino]-1-propanol as a residue.

Aufarbeitung

  1. temperaturerefluxed overnight
  2. temperatureThe reaction mixture is cooled
  3. customevaporated
  4. extractionthe product is extracted with methylbenzene
  5. washThe extract is washed with water
  6. customdried
  7. filtrationfiltered
  8. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-3cf7f60be5d04e27a25f57e8e5833753
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04175129

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