Tetrahydrofuran → 4-amino-N,N,2-trimethylbenzamide

HRID 469825Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469825
[CH3:1][C:2]1[CH:12]=[C:11]([N+:13]([O-])=O)[CH:10]=[CH:9][C:3]=1[C:4]([N:6]([CH3:8])[CH3:7])=[O:5].C1COCC1>CO.[Pd]>[NH2:13][C:11]1[CH:10]=[CH:9][C:3]([C:4]([N:6]([CH3:8])[CH3:7])=[O:5])=[C:2]([CH3:1])[CH:12]=1

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 62604610N,N,2-trimethyl-4-nitrobenzamide

Produkt 1

HCID 536229124-amino-N,N,2-trimethylbenzamide

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 1.7 g (8.16 mmol) 2,N,N-trimethyl-4-nitro-benzamide in 45 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Fluka 75990). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-8cd8849841184a608b42eb6ad4f7817e
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629168B2

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