Tetrahydrofuran → 4-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

HRID 469832Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 469832
[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1.C1COCC1>CO.[Pd]>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=2[CH3:20])[CH2:7][CH2:6]1

Komponenten

5

Edukt 2

HCID 8028TetrahydrofuranHCID 674588251-(2-Methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine

Produkt 1

HCID 666173884-[4-(2-Methoxy-ethyl)-piperazin-1-yl]-3-methyl-phenylamine

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 0.85 g (3.04 mmol) 1-(2-methoxy-ethyl)-4-(2-methyl-4-nitro-phenyl)-piperazine in 20 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g 10% Pd/C (Engelhard 4505). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the title compound as an oil.

Aufarbeitung

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5cf1bcbbf98a4561a3630887a21c097b
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629168B2

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