HCID 59784811, Verbindung → HCID 59784760, Verbindung

HRID 470333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 470333
NC1C(C(O)=O)=CN(C2N=CC3CC[C:14]4[CH:20]=[C:21]([O:24][CH3:25])C=C[C:13]=4[C:12]=3[N:11]=2)N=1.Br[C:27]1[CH:39]=[CH:38][C:30]2[NH:31]C(C(Cl)(Cl)Cl)=[N:33][C:29]=2[CH:28]=1>CC(N(C)C)=O>[NH2:33][C:29]1[CH:28]=[C:27]([C:20]2[C:21]([O:24][CH3:25])=[N:11][CH:12]=[CH:13][CH:14]=2)[CH:39]=[CH:38][C:30]=1[NH2:31]

Komponenten

4

Edukt 2

HCID 59784811HCID 59784811, VerbindungHCID 178478477HCID 178478477, Verbindung

Produkt 1

HCID 59784760HCID 59784760, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

A solution of salicylaldehyde derivative 1 (0.5 mmol) and diamine 2 (0.176 g, 0.5 mmol) in dimethylacetamide (4 mL) was stirred at 100° C. for 12 h. Solvent was evaporated and the residue was purified by preparative HPLC to give benzimidazole derivative 3.

Aufarbeitung

  1. customSolvent was evaporated
  2. customthe residue was purified by preparative HPLC

Quellen und Nachweise

ORD-Eintrag
ord-767a453eef514022b2180d55ee167413
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629147B2

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