tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate → tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

HRID 470617Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 470617
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]#[N:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>C(O)C.[Pd]>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15]#[N:16])[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Komponenten

4

Edukt 1

HCID 15326949tert-Butyl 4-(cyanomethylidene)piperidine-1-carboxylate2×

Produkt 1

HCID 22248390tert-Butyl 4-(cyanomethyl)piperidine-1-carboxylate

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

4-Cyanomethylene-piperidine-1-carboxylic acid tert-butyl ester (compound of Example 14; 6.9 g, 31.0 mmol) and Pd/C (0.7 g) in ethanol (150 mL) was maintained under hydrogen atmosphere for 8 h. The reaction mixture was filtered through Celite and the solvent was evaporated to afford the title compound.

Aufarbeitung

  1. filtrationThe reaction mixture was filtered through Celite
  2. customthe solvent was evaporated

Quellen und Nachweise

ORD-Eintrag
ord-818dcfa918dd4a16a8512cc81129a5aa
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629277B2

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