Toluene → HCID 178444032, Verbindung

HRID 470636

Reaktionsgleichung

Reaktionsgleichung von HRID 470636
Cl.[NH2:2][OH:3].C(=O)(O)[O-].[Na+].[C:9](#[N:15])[CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C:16]1(C)C=CC=CC=1>C(O)(C)C>[OH:3][NH:2][C:9](=[NH:15])[CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:16]

Komponenten

6

Edukt 4

HCID 1140TolueneHCID 12352HexanenitrileHCID 443297Hydroxyamine hydrochlorideHCID 516892Sodium Bicarbonate

Produkt 1

HCID 178444032HCID 178444032, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

To a solution of 0.93 g (13.4 mmol) of hydroxylamine hydrochloride in 11 mL of isopropyl alcohol, 1.66 g (19.78 mmol) of sodium bicarbonate was added. The resulting mixture was stirred at 25° C. to 30° C. for 10-15 min. 1.0 g (8.9 mmol) of hexanenitrile was added and stirred at 80° C. to 85° C. for 3-4 h. After completion of the reaction, the reaction mixture was cooled to 25° C. to 30° C., filtered and washed with 2 mL of isopropyl alcohol. The filtrate was collected and distilled out completely to obtain a crude residue, which was chased with 5 mL of toluene, to yield the title compound.

Aufarbeitung

  1. stirringstirred at 80° C. to 85° C. for 3-4 h
  2. customAfter completion of the reaction
  3. temperaturethe reaction mixture was cooled to 25° C. to 30° C.
  4. filtrationfiltered
  5. washwashed with 2 mL of isopropyl alcohol
  6. customThe filtrate was collected
  7. distillationdistilled out completely
  8. customto obtain a crude residue, which

Quellen und Nachweise

ORD-Eintrag
ord-94393496b6614b9f9ac5cc691ce5fcfe
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629277B2

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