Sodium Bicarbonate → 4,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione

HRID 47108

Reaktionsgleichung

Reaktionsgleichung von HRID 47108
[CH3:1][C:2]1([CH3:21])[C:11]2[C:6](=[C:7]([N+:16]([O-:18])=[O:17])[C:8]([NH:12][C:13]([CH3:15])=[O:14])=[CH:9][CH:10]=2)[C:5](=[O:19])[NH:4][C:3]1=[O:20].[C:22](=O)(O)[O-].[Na+]>C(OC(=O)CC)(=O)CC>[CH3:1][C:2]1([CH3:21])[C:11]2[C:6](=[C:7]([N+:16]([O-:18])=[O:17])[C:8]([NH:12][C:13](=[O:14])[CH2:15][CH3:22])=[CH:9][CH:10]=2)[C:5](=[O:19])[NH:4][C:3]1=[O:20]

Komponenten

4

Edukt 2

HCID 516892Sodium BicarbonateHCID 118331714,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione

Produkt 1

HCID 203849304,4-Dimethyl-7-propionylamino-8-nitro-2H,4H-isoquinoline-1,3-dione

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31263Propionic anhydrideLösungsmittel

Versuchsvorschrift

29.1 gm of 4,4-dimethyl-7-acetamino-8-nitro-2H,4H-isoquinoline-1,3-dione were refluxed for 4 hours with 50 ml of propionic acid anhydride. The mixture was then poured into ice water and neutralized with sodium bicarbonate. The obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1).

Aufarbeitung

  1. customThe obtained precipitate was purified on a silicagel column (eluant: chloroform/acetone 19:1)

Quellen und Nachweise

ORD-Eintrag
ord-4924df22b6b444dcb4a340a120e8213e
Quelldatensatz
uspto-grants-1979_11
Patentnummer
US04176184

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