Hydrochloric Acid → 2-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

HRID 471169

Reaktionsgleichung

Reaktionsgleichung von HRID 471169
Cl.C([O:4][CH:5](OCC)[CH2:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH2:14][CH2:15][OH:16])=[C:10]([F:17])[C:9]=1[F:18])C>O1CCOCC1.O>[F:18][C:9]1[C:10]([F:17])=[C:11]([CH2:14][CH2:15][OH:16])[CH:12]=[CH:13][C:8]=1[O:7][CH2:6][CH:5]=[O:4]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 579889892-(4-(2,2-Diethoxyethoxy)-2,3-difluorophenyl)ethanol

Produkt 1

HCID 866367532-(2,3-Difluoro-4-(2-hydroxyethyl)phenoxy)acetaldehyde

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

Concentrated hydrochloric acid (5 mL) was added to a solution of 2-(4-(2,2-diethoxyethoxy)-2,3-difluorophenyl)ethanol (example 77, step c) (0.49 g) in 1,4-dioxane (10 mL) and the resulting mixture was stirred for 1 h. The mixture was carefully diluted with water (50 mL) and extracted with ethyl acetate (3×50 mL). The combined organics were washed with water (50 mL) and brine (50 mL), dried over sodium sulphate, filtered and evaporated to give the subtitled compound, which was used directly. Yield 0.31 g.

Aufarbeitung

  1. extractionextracted with ethyl acetate (3×50 mL)
  2. washThe combined organics were washed with water (50 mL) and brine (50 mL)
  3. dry with materialdried over sodium sulphate
  4. filtrationfiltered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d9371c8a2384405bb422374284e2c1fb
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08629271B2

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