4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide → 4-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

HRID 471442Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 471442
[N+:1]([C:4]1[C:17]([CH3:18])=[CH:16][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:14])[CH3:13])=[O:9])=[CH:6][C:5]=1[CH3:19])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:19])=[CH:6][C:7]([C:8]([NH:10][CH2:11][C:12]([OH:15])([CH3:13])[CH3:14])=[O:9])=[CH:16][C:17]=1[CH3:18]

Komponenten

4

Edukt 1

HCID 867038834-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide

Produkt 1

HCID 867038844-amino-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamideAusbeute 84,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-Nitro-N-(2-hydroxy-2-methyl-propyl)-3,5-dimethyl-benzamide (1.2 g, 4.51 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% palladium on activated carbon (120 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 900 mg).

Aufarbeitung

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-67c5733925104d7ca320afd798f14b04
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633182B2

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