N,3,5-Trimethyl-4-nitrobenzamide → 4-amino-N,3,5-trimethylbenzamide

HRID 471447Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 471447
[N+:1]([C:4]1[C:13]([CH3:14])=[CH:12][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:6][C:5]=1[CH3:15])([O-])=O>CO.[Pd]>[NH2:1][C:4]1[C:5]([CH3:15])=[CH:6][C:7]([C:8]([NH:10][CH3:11])=[O:9])=[CH:12][C:13]=1[CH3:14]

Komponenten

4

Edukt 1

HCID 86697180N,3,5-Trimethyl-4-nitrobenzamide

Produkt 1

HCID 668742744-amino-N,3,5-trimethylbenzamideAusbeute 99,4 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

4-Nitro-3,5,N-trimethyl-benzamide (1.0 g, 4.8 mmol) is suspended in methanol (10 mL) and hydrogenated at 3 bar for 3 hours using 10% Palladium on activated carbon (100 mg) as the catalyst. The mixture is filtered through celite and the solvent removed under vacuum to give the title compound (Yield 850 mg).

Aufarbeitung

  1. filtrationThe mixture is filtered through celite
  2. customthe solvent removed under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-4c035677036649519800a4b9ee9957a0
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633182B2

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