Chlorosulfamic acid → N-(2-cyano-4-fluorophenyl)sulfamide

HRID 471542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 471542
[NH2:1][C:2]1[CH:9]=[CH:8][C:7]([F:10])=[CH:6][C:3]=1[C:4]#[N:5].[S:11](Cl)(=[O:14])(=[O:13])[NH2:12]>CC(N(C)C)=O>[C:4]([C:3]1[CH:6]=[C:7]([F:10])[CH:8]=[CH:9][C:2]=1[NH:1][S:11]([NH2:12])(=[O:14])=[O:13])#[N:5]

Komponenten

4

Edukt 2

HCID 24499Chlorosulfamic acidHCID 27377042-Amino-5-fluorobenzonitrile

Produkt 1

HCID 67401076N-(2-cyano-4-fluorophenyl)sulfamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 31374DimethylacetamideLösungsmittel

Versuchsvorschrift

A solution of 2-amino-5-fluorobenzonitrile (136 mg, 1 mmol) and sulfamoyl chloride (114 mg, 1 mmol) in DMA (2 mL) was stirred at room temperature for 2 hours. The reaction was purified by Varian HPLC (10% Acetonitrile/Water) to give N-(2-Cyano-4-fluorophenyl)sulfamide as a pale-white solid. 1H NMR (400 MHz, DMSO-d6) 7.18 (m, 2H), 7.56-7.60 (dd J=8.8 Hz, 2.8 Hz 2H), 9.44 (s, 1H).

Aufarbeitung

  1. customThe reaction was purified by Varian HPLC (10% Acetonitrile/Water)

Quellen und Nachweise

ORD-Eintrag
ord-50c76c4add394449a240cc545d51ef05
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08633186B2

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