Nitric Acid → HCID 178512554, Verbindung

HRID 47202Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47202
[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH2:4].[N+:10]([O-:13])([OH:12])=[O:11].[N:14]#[C:15][NH2:16]>CCO>[N+:10]([O-:13])([OH:12])=[O:11].[F:1][C:2]1[CH:8]=[C:7]([F:9])[CH:6]=[CH:5][C:3]=1[NH:4][C:15]([NH2:16])=[NH:14]

Komponenten

5

Edukt 3

HCID 944Nitric AcidHCID 97092,4-DifluoroanilineHCID 9864Cyanamide

Produkt 1

HCID 178512554HCID 178512554, VerbindungAusbeute 40 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

To a mixture of 2,4-difluoroaniline (25 mmol, 3.2 g) in EtOH (10 mL) in an ice bath was added nitric acid (69% aq soln.; 1.8 mL) dropwise. After completion of the addition cyanamide (50% aq. soln.; 4 mL) was added. The reaction mixture was refluxed under N2 for 22 h. The solvent was evaporated. The solid residue was washed with EtOH and was dried under high vacuum to afford the title compound as a purple solid (2.32 g, 40%).

Aufarbeitung

  1. additionwas added
  2. temperatureThe reaction mixture was refluxed under N2 for 22 h
  3. customThe solvent was evaporated
  4. washThe solid residue was washed with EtOH
  5. customwas dried under high vacuum

Quellen und Nachweise

ORD-Eintrag
ord-f864972e90794ee39827fc1c7b384905
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699854B2

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