Diethyl Ether → 3-Ethoxycarbonyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

HRID 47217

Reaktionsgleichung

Reaktionsgleichung von HRID 47217
[NH2:1][C:2](=[N:8][O:9][C:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][C:17]=1[C:18]([F:21])([F:20])[F:19])=O)[C:3]([O:5][CH2:6][CH3:7])=[O:4].C(OCC)C>C1(C)C(C)=CC=CC=1.C1(C)C=CC=CC=1>[CH2:6]([O:5][C:3]([C:2]1[N:1]=[C:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][C:17]=2[C:18]([F:21])([F:20])[F:19])[O:9][N:8]=1)=[O:4])[CH3:7]

Komponenten

5

Edukt 2

HCID 3283Diethyl EtherHCID 73994277Ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate

Produkt 1

HCID 227440743-Ethoxycarbonyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 1140TolueneLösungsmittelHCID 7237O-XyleneLösungsmittel

Versuchsvorschrift

20 g of ethyl 2-amino-2-(4-trifluormethyl-3-pyridinecarbonyloxyimino)-acetate are dissolved in 200 ml of a mixture of xylene and toluene and admixed with 5 g of Amberlyst 15. The mixture is boiled at 125-130° C. for 6 h using a Dean-Stark apparatus. After the reaction has ended, the mixture is cooled and admixed with a small amount of diethyl ether. The mixture is filtered with suction through a glass filter frit, and the solution is then concentrated. This gives 15.8 g of the product as a yellow oil.

Aufarbeitung

  1. customfor 6 h
  2. temperaturethe mixture is cooled
  3. filtrationThe mixture is filtered with suction through a glass
  4. filtrationfilter frit
  5. concentrationthe solution is then concentrated

Quellen und Nachweise

ORD-Eintrag
ord-e9a27cfcb86a4e179942c262d9c4839d
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699853B2

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