Hydrochloric Acid → 3-(2-Benzofuran-1(3H)-ylidene)-1,3-dihydro-2H-indol-2-one

HRID 47246

Reaktionsgleichung

Reaktionsgleichung von HRID 47246
[H-].[Na+].[NH:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][C:4]1=[O:12].[C:13]1([C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][O:15]1)=O.Cl>CN(C=O)C.O>[C:13]1(=[C:5]2[C:6]3[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=3)[NH:3][C:4]2=[O:12])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][O:15]1

Komponenten

7

Edukt 4

HCID 313Hydrochloric AcidHCID 6885PhthalideHCID 24758Sodium hydrideHCID 321710Oxindole

Produkt 1

HCID 687793813-(2-Benzofuran-1(3H)-ylidene)-1,3-dihydro-2H-indol-2-oneAusbeute 47 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6228DimethylformamideLösungsmittel3×

Versuchsvorschrift

To a suspension of sodium hydride (6.0 g, 150 mmol, 60% in mineral oil) in 300 mL DMF was added oxindole (10.0 g, 75.1 mmol) in 50 mL DMF over 8 min. After stirring for 15 min at room temperature, a solution of phthalide (13.1 g, 97.6 mmol) in 50 mL DMF was added over 1 min. The mixture was stirred for 1.25 h, then poured into 1100 mL H2O. Addition of 4% aqueous HCl solution gave a yellow solid which was filtered and rinsed with H2O to give the title compound (8.75 g, 47%).

Aufarbeitung

  1. stirringThe mixture was stirred for 1.25 h
  2. customgave a yellow solid which
  3. filtrationwas filtered
  4. washrinsed with H2O

Quellen und Nachweise

ORD-Eintrag
ord-109acb10850e49059707c2d4542b8145
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699863B1

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