Ammonium Hydroxide → [2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

HRID 47274

Reaktionsgleichung

Reaktionsgleichung von HRID 47274
[N:1]([CH2:4][CH2:5][CH:6]1[CH2:10][CH2:9][CH2:8][N:7]1[CH3:11])=[C:2]=[S:3].[OH-].[NH4+:13]>>[CH3:11][N:7]1[CH2:8][CH2:9][CH2:10][CH:6]1[CH2:5][CH2:4][NH:1][C:2]([NH2:13])=[S:3]

Komponenten

3

Edukt 2

HCID 14923Ammonium Hydroxide2×HCID 219923282-(2-Isothiocyanatoethyl)-1-methylpyrrolidine

Produkt 1

HCID 21992305[2-(1-Methyl-pyrrolidin-yl)ethyl] thiourea

Versuchsvorschrift

The 2-(2-isothiocyanatoethyl)-1-methylpyrrolidine and concentrated ammonium hydroxide (3 mL) were heated at 100° C. for 30 minutes. Additional ammonium hydroxide (1 mL) was added and heating was continued for an additional 30 minutes. The reaction mixture was allowed to cool to room temperature and then it was lyophilized to give [2-(1-methylpyrrolidin-2-yl)ethyl]thiourea as a very viscous colorless oil.

Aufarbeitung

  1. temperatureheating

Quellen und Nachweise

ORD-Eintrag
ord-b966538370894aab817f4a3432f2391f
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699866B2

Verknüpfte Notizen

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