Sodium borohydride → (2-Fluoro-4-iodopyridin-3-yl)methanol

HRID 47359

Reaktionsgleichung

Reaktionsgleichung von HRID 47359
[BH4-].[Na+].[F:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1>O1CCCC1>[F:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([I:12])[CH:7]=[CH:6][N:5]=1

Komponenten

4

Edukt 2

HCID 4311764Sodium borohydrideHCID 99923282-Fluoro-4-iodopyridine-3-carbaldehyde

Produkt 1

HCID 11021396(2-Fluoro-4-iodopyridin-3-yl)methanol

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

0.72 g (19.2 mmol) of sodium borohydride is added to a solution of 4 g (16 mmol) of 2-fluoro-4-iodo-3-pyridinecarbaldehyde (described in J.O.C., 1993, 58, pp. 7832) in 100 ml of tetrahydrofuran. The mixture is stirred at room temperature for 4 hours and then hydrolysed. The reaction mixture is extracted with ethyl acetate. The organic phases are dried and concentrated to yield the expected product.

Aufarbeitung

  1. extractionThe reaction mixture is extracted with ethyl acetate
  2. customThe organic phases are dried
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-d094e11700ea421e989ed6c166b22473
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699876B2

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