Hydrochloric Acid → HCID 178462754, Verbindung
Reaktionsgleichung
CO[CH:3](OC)[CH2:4][NH:5][C:6](=[O:12])[C:7]([NH:9][CH2:10][CH3:11])=[O:8].Cl>C(O)(=O)C>[CH2:4]([N:5]1[CH:11]=[CH:10][N:9]=[C:7]([OH:8])[C:6]1=[O:12])[CH3:3]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
67.5 g (330 mM) of N-(2,2-dimethoxyethyl)-N′-ethylethanediamide and 2 ml of concentrated hydrochloric acid in 390 ml of acetic acid were refluxed under stirring for 1 h. The solvent was removed under vacuum to give an oil, which was further purified by silica gel column chromatography, using dichloromethane/methanol (95/5) as eluant to give 37 g of 1-ethyl-3-hydroxy pyrazine-2(1H)-one, as an oil. Yield: 79.5%.
Aufarbeitung
- customThe solvent was removed under vacuum
- customto give an oil, which
- customwas further purified by silica gel column chromatography
Quellen und Nachweise
- ORD-Eintrag
- ord-7d5f4710dcf4451e81b0aebd7c49e2a7
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08637522B2
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