2-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl ester → HCID 54346018, Verbindung

HRID 47438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 47438
[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.[H][H]>CO.[Pd]>[CH3:1][O:2][C:3](=[O:22])[C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[O:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1

Komponenten

5

Edukt 2

HCID 540755342-(4-Methoxy-phenoxy)-5-nitro-benzoic acid methyl esterHCID 178418361HCID 178418361, Verbindung

Produkt 1

HCID 54346018HCID 54346018, VerbindungAusbeute 96,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23938PalladiumKatalysatorHCID 887MethanolLösungsmittel

Versuchsvorschrift

The compound of step 1 (2.3 g) in methanol (150 ml) containing 10% Pd/C (0.5 g) was hydrogenated under one atmosphere of hydrogen for 18 h. The mixture was filtered (kieselguhr) and solvent removed from the filtrate under reduced pressure to give the title compound (2.0 g) as a yellow oil. 1H NMR (CDCl3) δ: 3.69 (2H, brs), 3.77 (6H, s), 6.76-6.87 (6H, m), 7.19 (1H, d, J=2.5 Hz).

Aufarbeitung

  1. filtrationThe mixture was filtered (kieselguhr) and solvent
  2. customremoved from the filtrate under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-aaf8ecbfeabc41609627124b2c8edee2
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699879B1

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