Triethylamine → HCID 86662381, Verbindung

HRID 474449Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 474449
[C:1]([O:5][C:6](=[O:21])[NH:7][CH:8]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1)[CH2:9][CH2:10][OH:11])([CH3:4])([CH3:3])[CH3:2].C(N([CH2:27][CH3:28])CC)C.[C:29]1(C)[C:30]([S:35](Cl)(=[O:37])=[O:36])=[CH:31][CH:32]=C[CH:34]=1>ClCCl.O>[C:1]([O:5][C:6]([NH:7][CH:8]([C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([N+:18]([O-:20])=[O:19])[CH:13]=1)[CH2:9][CH2:10][O:11][S:35]([C:30]1[CH:31]=[CH:32][C:27]([CH3:28])=[CH:34][CH:29]=1)(=[O:37])=[O:36])=[O:21])([CH3:4])([CH3:2])[CH3:3]

Komponenten

6

Edukt 3

HCID 8471TriethylamineHCID 8623o-Toluenesulfonyl chlorideHCID 19104047HCID 19104047, Verbindung

Produkt 1

HCID 86662381HCID 86662381, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 962WaterLösungsmittelHCID 6344DichloromethaneLösungsmittel3×

Reaktionsbedingungen

Temperatur
0 °C

Versuchsvorschrift

2 g (6.75 mmol) [3-Hydroxy-1-(3-nitro-phenyl)-propyl]-carbamic acid tert-butyl ester were dissolved in 10 ml dichloromethane and 1.4 ml (20.1 mmol) triethylamine. Under ice-cooling, 1.54 g (8.10 mmol) toluene sulfonic acid chloride in 5 ml dichloromethane were added and the mixture was stirred 30 min at 0° C. and 18 h at room temperature. The reaction mixture was diluted with 10 ml water and 30 ml dichloromethane, the organic layer was separated and washed with water, dried over Na2SO4 and evaporated to dryness. The crude product was used without further purification.

Aufarbeitung

  1. temperatureUnder ice-cooling
  2. customthe organic layer was separated
  3. washwashed with water
  4. dry with materialdried over Na2SO4
  5. customevaporated to dryness
  6. customThe crude product was used without further purification

Quellen und Nachweise

ORD-Eintrag
ord-f294f98c0ac3454ba5c0d23bf4eae68b
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637532B2

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