Dimethylformamide → HCID 178526937, Verbindung

HRID 47460

Reaktionsgleichung

Reaktionsgleichung von HRID 47460
[O-:1]CC.[K+].[CH3:5][C:6]1[N:10]([C:11]2[CH:12]=[N:13][CH:14]=[CH:15][C:16]=2[C:17]([O:19]CC)=O)[N:9]=[N:8][N:7]=1.CN(C)C=O>C(O)(=O)C>[OH2:1].[N:9]1[N:10]2[C:11]3[C:16]([C:17]([OH:19])=[CH:5][C:6]2=[N:7][N:8]=1)=[CH:15][CH:14]=[N:13][CH:12]=3

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 22172739ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylateHCID 23670592Potassium ethoxide

Produkt 1

HCID 178526937HCID 178526937, VerbindungAusbeute 90,9 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 176Acetic AcidLösungsmittel

Versuchsvorschrift

Potassium ethoxide (20.2 g) was added to a mixture of ethyl 3-(5-methyl-1H-tetrazol-1-yl)pyridine-4-carboxylate (28 g) and dimethylformamide (280 mL). The reaction mixture was allowed to stir at ambient temperature overnight then poured into cold dilute acetic acid. The resulting precipitate was collected, washed with water and dried to provide 22.4 g of tetrazolo[1,5-a][1,7]naphthyridin-5-ol hydrate as a solid, m.p. 247-248° C. (decomposition). Analysis: Calculated for C8H5N5O: %C, 46.83; %H, 3.44; %N, 34.13. Found: %C, 46.48; %H, 3.42; %N, 34.03.

Aufarbeitung

  1. customThe resulting precipitate was collected
  2. washwashed with water
  3. customdried

Quellen und Nachweise

ORD-Eintrag
ord-bd0cdde275de498d9a53580003c5b510
Quelldatensatz
uspto-grants-2004_03
Patentnummer
US06699878B2

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