Formic Acid → 4-BROMO-6-FLUORO-1H-BENZO[D]IMIDAZOLE

HRID 475145Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 475145
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[C:4]([NH2:9])[C:3]=1[NH2:10].[CH:11](O)=O>>[Br:1][C:2]1[C:3]2[N:10]=[CH:11][NH:9][C:4]=2[CH:5]=[C:6]([F:8])[CH:7]=1

Komponenten

3

Edukt 2

HCID 284Formic AcidHCID 140299893-Bromo-5-fluorobenzene-1,2-diamine

Produkt 1

HCID 529878624-BROMO-6-FLUORO-1H-BENZO[D]IMIDAZOLE

Reaktionsbedingungen

Temperatur
110 °C

Versuchsvorschrift

A mixture of 3-bromo-5-fluorobenzene-1,2-diamine (10.1 g, 49 mmol) in formic acid (20 mL) was heated at 110° C. overnight. The reaction mixture was concentrated, and to the residue was added MeOH (5 mL) to form a precipitate. The precipitate was filtered and washed with MeOH (2 mL) to afford 4-bromo-6-fluoro-1H-benzo[d]imidazole as a yellow solid (10 g, yield, 73%). MS (ESI): m/z=215 [M+1]+.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated
  2. additionto the residue was added MeOH (5 mL)
  3. customto form a precipitate
  4. filtrationThe precipitate was filtered
  5. washwashed with MeOH (2 mL)
  6. customto afford

Quellen und Nachweise

ORD-Eintrag
ord-0aca8d3d4229468da5e32b77f0b06e5a
Quelldatensatz
uspto-grants-2014_01
Patentnummer
US08637537B2

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