Formic Acid → HCID 178419331, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[C:4]([NH2:9])[C:5]([NH2:8])=[CH:6][CH:7]=1.[CH:10](O)=O>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]2[NH:8][CH:10]=[N:9][C:4]=2[CH:3]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 100 °C
Versuchsvorschrift
A mixture of 4-bromobenzene-1,2-diamine (4.0 g, 21.5 mmol) and formic acid (95%, 100 mL) was stirred at 100° C. overnight. The reaction mixture was cooled to RT and concentrated in vacuo to afford a dark oil. The crude oil was partitioned between EtOAc (500 mL) and NH3/H2O (50 mL). The EtOAc layer was separated and concentrated in vacuo to afford 4.5 g (100%) of 5-bromo-1H-benzo[d]imidazole (78) as brown solid: MS (ESI) m/z=197.0 (M+1).
Aufarbeitung
- temperatureThe reaction mixture was cooled to RT
- concentrationconcentrated in vacuo
- customto afford a dark oil
- customThe crude oil was partitioned between EtOAc (500 mL) and NH3/H2O (50 mL)
- customThe EtOAc layer was separated
- concentrationconcentrated in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-2cdb7cd6e94c4ed4b6a3107380ddf1cd
- Quelldatensatz
- uspto-grants-2014_01
- Patentnummer
- US08637537B2
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